Candiflox Ear Drops 5ml

Composition

This ear drop is a Clear, pyrogen-free, preservative-free otic solution. Each ml contains-

• Ofloxacin BP 3 mg
• Clotrimazole BP 10 mg
• Beclomethasone Dipropionate BP 0.25 mg
• Lidocaine Hydrochloride BP 20 mg.

How to use Ear Drop?

• Wash your hands thoroughly before administering the ear drops.
• Ensure the ear drop bottle is at room temperature to avoid dizziness from cold drops.
• Tilt your head to one side so that the ear needing treatment is facing up.
• For adults and children older than 3 years: Gently pull the ear lobe up and backward.
• For pediatric patients (younger than 3 years): Gently pull the ear lobe down and backward.
• Hold the dropper close to the ear without touching it to avoid contamination.
• Instill the prescribed number of drops into the ear canal.
• Keep your head tilted for a few minutes to allow the drops to penetrate deep into the ear canal.
• Avoid touching the dropper tip with your fingers or the ear to maintain sterility.
• Clean the dropper with a clean tissue and close the bottle tightly.
• Wash your hands again after administering the drops.

Side Effects of Candiflox Ear Drop

• Application site irritation
• Ear discomfort

Quick Suggestions:

• Your doctor has prescribed Candiflox Ear Drop for the treatment of ear infections.
• Finish the prescribed dose even if you feel better as stopping the treatment earlier may reverse the symptoms.
• Do not touch the tip of the dropper, or of your ear to prevent contamination.
• Inform your doctor if you notice mild irritation in the ear, dizziness, headache, earache, or changes in taste may occur.
• Make sure to use it within 4 weeks of opening the bottle.

Indications:

Candiflox Ear Drop is indicated for the treatment of superficial bacterial and fungal infections of the external auditory canal and the middle ear, caused by organisms susceptible to the action of Ofloxacin and Clotrimazole.

Pharmacology

It is a combination of an antibacterial, an antifungal, an anti-inflammatory, and a topical local anesthetic agent. This ear drop has been specially formulated to maintain the natural environment of the external ear canal.

• Ofloxacin is a fluoroquinolone that has a broad spectrum of activity against otic pathogens without ototoxicity. Hence Ofloxacin is preferred to Aminoglycosides for any application within the middle ear space. Ofloxacin exerts antibacterial activity by inhibiting the DNA gyrase of bacteria. Ofloxacin has been shown to be active against the following organisms responsible for otic infections: Gram-positive: Staphylococcus aureus, Streptococcus pneumoniae. Gram-negative: Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa.
• Clotrimazole is a synthetic imidazole derivative, which is a broad-spectrum antifungal agent that exerts fungicidal activity against fungi responsible for superficial mycotic infections affecting the outer or middle ear including Candida, Microsporum & Trichophyton. Clotrimazole inhibits Cytochrome P-450 synthesis of Ergosterol, which decreases fungal cell wall integrity and thus inhibits fungal growth. Clotrimazole also has activity against certain bacteria such as Streptococci and Staphylococci. The antibacterial effect of Clotrimazole is advantageous to treat mixed bacterial-fungal infections.
• Beclomethasone Dipropionate is a potent steroid as compared with other topical corticosteroids. Beclomethasone like other topical corticosteroids, has anti-inflammatory, antipruritic, and vasoconstrictive properties. It induces phospholipase A2 and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of prostaglandins, leukotrienes, and other inflammatory mediators.
• Lidocaine Hydrochloride is a topical local anesthetic that helps to reduce pain and stinging in the ear.

Dosage & Administration

Adults & Children:

• Dosage: Instill 2-5 drops three to four times daily into the affected ear for 7-14 days.

Specific Conditions:

• Otitis Externa with Intact Tympanic Membrane: Suitable for patients aged 6 months and older.
• Chronic Suppurative Otitis Media with Perforated Tympanic Membrane: Suitable for patients aged 12 years and older.

Interactions for Lidocaine+Clotrimazole+Beclometasone+Ofloxacin

Drug-Drug Interactions:

• Pain Killers: Acetaminophen, aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam.
• Corticosteroids: Prednisone.
• Anti-diabetics: Insulin.
• Respiratory Drugs: Theophylline.
• Blood Thinners: Warfarin.
• Water Pills: Diuretics.
• Antidepressants.
• Antacids: Containing calcium, magnesium, or aluminum.

Drug-Food Interaction:

• No established interactions. However, avoiding fatty foods, alcohol, and caffeine can help manage infections.

Drug-Disease Interaction:

• Inform your doctor if you have a history of allergic reactions to medicines, diabetes, liver diseases, cataracts, glaucoma, or adrenal gland problems before using Lidocaine+Clotrimazole+Beclometasone+Ofloxacin.

Contraindications

Lidocaine+Clotrimazole+Beclometasone+Ofloxacin is contraindicated in patients with sensitivity to Ofloxacin or other quinolone, or to any of the components of this medication. It is contra-indicated in viral infections of the ear.

Pregnancy & Lactation

Safety during pregnancy or lactation has not been established. It is not known whether the active substances pass into breast milk when applied topically. Therefore, the potential benefit of this product during pregnancy or lactation should be weighed against possible hazards to the fetus or the nursing infant.

Precautions & Warnings

• Do not use more than the recommended dose.
• Complete the full course of treatment even if symptoms improve.
• Consult your doctor if you experience persistent side effects or if symptoms worsen.
• If you have any underlying conditions or are taking other medications, inform your doctor before using Candiflox Ear Drops.

Storage Conditions:

Store the ear drops as per the instructions on the packaging, keeping them out of reach of children and pets.